Aprecap

Details:

Description:

Aprecap capsules are used to prevent nausea and vomitingassociated with cancer chemotherapy and are used as combination therapy withother mediations for both highly and moderately emetogenic (vomiting inducing)chemotherapy.  Chemotherapy is the use of cytotoxic drugs to kill cancercells, which grow more rapidly than most normal cells, and nausea and vomitingare common side effects of chemotherapy.    During chemotherapythe drugs stimulate the vomiting reflex that is triggered in the brain. Aprecap capsules block the vomiting reflex and prevent nausea and vomitinginduced by these drugs.

Direction of use:

You should take your Aprecap capsules swallowed whole, witha glass of water, with or without food, as part of a 3-day regimen thatincludes a corticosteroid and a 5-HT3 antagonist.  You should consume yourfirst capsule (125mg) on day 1, one hour before starting chemotherapy. You should take your next two capsules (80mg) each on days 2 and 3 in themorning.  You should take your Aprecap capsules in addition to otherantiemetic medications as recommended by your doctor/pharmaci/nurse.

Side Effects:

Constipation

Indigestion

Headache

Tiredness

Loss of appetite

Hiccup

Increased liver enzymes

Precautions:

You should not use Aprecap capsules if you:

are allergic to aprepitant or any ingredients in Aprecap

are pregnant or are breastfeeding

have liver disease

are taking medicines that interact with Aprecap, includingthe anticoagulant warfarin, the antipsychotic pimozide, the antihistaminesterfenadine and astemizole, cisapride for reflux, hormonal contraceptives, thesedative midazolam, tolbutamide for diabetes, the antifungal ketoconazole, theantibiotic rifampicin, the antidepressant paroxetine, diltiazem for high bloodpressure St John's Wort.

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